Maintaining Eye Contact when addressing a large gathering

When you are speaking to a large audience, it may not be possible for you to establish eye contact with everyone in the room. So, how do you give the perception to everyone in the room that you are talking to them?

You can divide the audience into logical sections/groups. When delivering your speech, look at one person in each section/group. The others who are sitting around that person would also get the feeling that you are talking to them. You can even pick a person who gives you more comfort feeling, in a group. Make sure to give each section of the room,  equal time and energy. Also, do not neglect the people in the back!